Tetrahydrothiophene → 1-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide

HRID 393500

반응식

HRID 393500 반응식
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][CH2:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10].C(OCC)(=O)C>C(#N)C>[Br-:6].[O:13]=[C:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH2:7][S+:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 1127TetrahydrothiopheneHCID 8857Ethyl AcetateHCID 21642Bromopinacolone

생성물 1

HCID 225645781-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide수율 80.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

In 100 ml of acetonitrile was dissolved 11.8 g of tetrahydrothiophene, to the solution was gradually added 20 g of 1-bromo-3,3-dimethyl-2-butanone. The mixture was stirred at room temperature for 2 days to deposit powder. After adding 100 ml of ethyl acetate to the reaction solution, the powder was collected by filtration, washed with ethyl acetate and dried to obtain 24 g of 2-oxo-3,3-dimethylbutyltetrahydrothiophenium bromide.

후처리

  1. filtrationthe powder was collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

출처 및 근거

ORD 기록
ord-36e13cc4264d4906ba7117d5054220e7
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06808862B2

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