Biphenyl → HCID 178474045, 화합물

HRID 393659노트

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HRID 393659 반응식
[C:1]([NH:4][C:5]1[N:10]=[C:9]([NH:11][CH:12]=[C:13]2[C:18](=[O:19])OC(C)(C)OC2=O)[CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C1(C2C=CC=CC=2)C=CC=CC=1.C1(OC2C=CC=CC=2)C=CC=CC=1>CCCCCC>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]2[C:9](=[N:11][CH:12]=[CH:13][C:18]=2[OH:19])[N:10]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 7095BiphenylHCID 7583Diphenyl EtherHCID 123544365-((6-Acetamido-2-pyridylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

생성물 1

HCID 178474045HCID 178474045, 화합물수율 83%

시약·촉매·용매 1

HCID 8058Hexane용매

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온도
250 °C

실험 절차

5-((6-Acetamido-2-pyridylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (1.3 g, 4.3 mmol) was added in portions to a stirred mixture of biphenyl (13.3 ml) and phenyl ether (36.8 ml) heated at 250° C. and the resulting mixture was stirred for 1 hour at 250° C. The mixture was allowed to cool and was diluted with hexane. The precipitate was collected by filtration and dried to give 2-acetamido-5-hydroxy-1,8-naphthyridine (720 mg, 83%).

후처리

  1. temperatureto cool
  2. filtrationThe precipitate was collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-2e24f521cd0f4d6ca51b85ee33644e16
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809097B1

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