Hydrochloric Acid → 2-Amino-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine

HRID 393661노트

반응식

HRID 393661 반응식
Cl.C([NH:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[N:9][CH:10]=[CH:11][C:12]=2[NH:16][C:17]2[CH:22]=[C:21]([OH:23])[C:20]([CH3:24])=[CH:19][C:18]=2[F:25])[N:7]=1)(=O)C.Cl>C(O)C>[NH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[N:9][CH:10]=[CH:11][C:12]=2[NH:16][C:17]2[CH:22]=[C:21]([OH:23])[C:20]([CH3:24])=[CH:19][C:18]=2[F:25])[N:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 226465602-Acetamido-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine hydrochloride

생성물 1

HCID 223464762-Amino-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine수율 76.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2-acetamido-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine hydrochloride (170 mg, 0.46 mmol), (prepared as described in Example 53), and concentrated hydrochloric acid (0.5 ml) in ethanol (10 ml) was heated at reflux for 2 hours. The mixture was allowed to cool and the organic volatiles were removed by evaporation. The aqueous residue was basified to pH9 with aqueous sodium hydroxide solution and the resulting precipitate was collected by filtration, washed with water and dried to give 2-amino-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine (100 mgs 76%).

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. temperatureto cool
  4. customthe organic volatiles were removed by evaporation
  5. filtrationthe resulting precipitate was collected by filtration
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-3dfb93076314459db3a7ce4325c3b611
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809097B1

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