(4-Nitrophenyl)acetic acid → Benzeneacetyl chloride, 4-nitro-

HRID 393848

반응식

HRID 393848 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[N+:7]([C:10]1[CH:15]=[CH:14][C:13](CC(O)=O)=[CH:12][CH:11]=1)([O-:9])=[O:8].CN(C=O)C>ClCCl>[N+:7]([C:10]1[CH:15]=[CH:14][C:13]([CH2:1][C:2]([Cl:4])=[O:3])=[CH:12][CH:11]=1)([O-:9])=[O:8]

참가 물질

5

반응물 3

HCID 4661(4-Nitrophenyl)acetic acidHCID 6228DimethylformamideHCID 65578Oxalyl chloride

생성물 1

HCID 6452210Benzeneacetyl chloride, 4-nitro-

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

3.75 ml (7.5 mmoles) of a 2M solution of oxalyl chloride in dichloromethane is added at 20° C. to a solution of 0.9 g (5 mmoles) of 4-nitrophenylacetic acid in a mixture composed of 10 ml of dichloromethane and 0.5 ml of DMF. After agitation for 30 minutes, the solution is concentrated under vacuum. The yellow oil obtained is used without additional purification in the following stage.

후처리

  1. concentrationthe solution is concentrated under vacuum
  2. customThe yellow oil obtained
  3. customis used without additional purification in the following stage

출처 및 근거

ORD 기록
ord-a2c4d1ad5c0049ed90be11c40f056869
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809088B2

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