Lithium Hydroxide → [Rac]-2-ethoxy-3-[2-methyl-4-(4-methyl-2-phenyl-thiazol-5-ylmethoxy)-phenyl]-propionic acid

HRID 394325노트

반응식

HRID 394325 반응식
C([O:3][C:4](=[O:31])[CH:5]([O:28][CH2:29][CH3:30])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[S:19][C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:17][C:16]=2[CH3:26])=[CH:9][C:8]=1[CH3:27])C.[Li+].[OH-]>>[CH2:29]([O:28][CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[S:19][C:18]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[N:17][C:16]=2[CH3:26])=[CH:9][C:8]=1[CH3:27])[C:4]([OH:31])=[O:3])[CH3:30]

참가 물질

3

반응물 2

HCID 3939Lithium HydroxideHCID 68616822[Rac]-2-ethoxy-3-[2-methyl-4-(4-methyl-2-phenyl-thiazol-5-ylmethoxy)-phenyl]-propionic acid ethyl ester

생성물 1

HCID 22647628[Rac]-2-ethoxy-3-[2-methyl-4-(4-methyl-2-phenyl-thiazol-5-ylmethoxy)-phenyl]-propionic acid

실험 절차

In analogy to the procedure described in example 10 d], [rac]-2-ethoxy-3-[2-methyl-4-(4-methyl-2-phenyl-thiazol-5-ylmethoxy)-phenyl]-propionic acid ethyl ester was treated with LiOH to obtain [rac]-2-ethoxy-3-[2-methyl-4-(4-methyl-2-phenyl-thiazol-5-ylmethoxy)-phenyl]-propionic acid as colorless oil.

후처리

  1. customdescribed in example 10 d

출처 및 근거

ORD 기록
ord-9a7ff642fb724ad7ae90243cfdbb07c5
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809110B2

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