Syringaldehyde → HCID 54431732, 화합물

HRID 394423

반응식

HRID 394423 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:12][CH3:13])[C:10]=1[OH:11])[CH:6]=O.[C:14]([O:20][CH2:21][CH3:22])(=[O:19])[CH2:15][C:16]([CH3:18])=[O:17].N1(CC(O)=O)CCCCC1>C1C=CC=CC=1>[CH2:21]([O:20][C:14](=[O:19])[C:15]([C:16](=[O:17])[CH3:18])=[CH:6][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[C:10]([OH:11])=[C:9]([O:12][CH3:13])[CH:8]=1)[CH3:22]

참가 물질

5

반응물 3

HCID 8655SyringaldehydeHCID 8868Ethyl AcetoacetateHCID 201097Piperidin-1-yl-acetic acid

생성물 1

HCID 54431732HCID 54431732, 화합물

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Monodemethylation of 3,4,5-trimethoxy benzaldehyde using sulphuric acid at 40° C. for 8 hours as described above in Example 1 yields syringaldehyde. Condensation of 3,5-Dimethoxy-4-hydroxy benzaldehyde (syringaldehyde) with ethyl acetoacetate in the presence of piperidine—acetic acid and benzene as the reaction medium at reflux temperature yields the title product. The reaction takes about 3.5 hours for completion.

후처리

  1. temperatureat reflux temperature

출처 및 근거

ORD 기록
ord-602d9d1954fa44eb829423fbca755f27
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06602515B2

연결된 노트

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