Methyl Nicotinate → nicotinic acid, potassium salt

HRID 3945

반응식

HRID 3945 반응식
[C:1]([O:9]C)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.C[Si](C)(C)[O-].[K+:16]>O1CCCC1>[C:1]([O-:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[K+:16]

참가 물질

4

반응물 2

HCID 7151Methyl NicotinateHCID 23668039Potassium trimethylsilanolate

생성물 1

HCID 23668574nicotinic acid, potassium salt수율 90.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The procedure of Example 1 was followed using methyl nicotinate (2.74 g, 20 mmol), potassium trimethylsilanolate (2.56 g, 20 mmol), dry tetrahydrofuran (50 mL), and a 5 h reaction time. Potassium nicotinate (2.93 g, 90% yield) was isolated as a white solid: 1H NMR (D2O, DSS) δ 7.55 (ddd, J=1.0, 5.3, 8.3 Hz, Ar--H, 1H), 8.25 (dt, J=1.9, 8.3, Ar--H, 1H), 8.93 ppm (m, Ar--H, 1H). Anal. Calcd. for C6H4KNO2 : C, 44.70; H, 2.50; N, 8.96; K, 24.26. Found: C, 42.28, 42.51, 44.97; H, 2.95, 2.74, 2.83; N, 8.54; K, 24.57.

후처리

  1. customa 5 h reaction time

출처 및 근거

ORD 기록
ord-67cb34ff7b604725838c1cc12c95539b
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723016

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