Hydrochloric Acid → 4-Bromo-2-chloro-N-(2-oxoethyl)benzamide
반응식
[Br:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][CH:10](OCC)[O:11]CC)=[O:7])=[C:4]([Cl:19])[CH:3]=1.Cl.O>C1COCC1>[Br:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][CH:10]=[O:11])=[O:7])=[C:4]([Cl:19])[CH:3]=1참가 물질
5
실험 절차
To a solution of 4-bromo-2-chloro-N-(2,2-diethoxyethyl)benzamide (14.88 g, 42.44 mmol) in THF (50 mL) was added 2N HCl (50 mL) at room temperature. After 24 hours, water (100 mL) was added to the mixture, then the mixture was extracted with ethyl acetate (100 mL×2), the organic layer was washed with water (50 mL), dried over MgSO4. Removal of the solvent, gave a title compound (6.98 g, 60% yield).
후처리
- extractionthe mixture was extracted with ethyl acetate (100 mL×2)
- washthe organic layer was washed with water (50 mL)
- dry with materialdried over MgSO4
- customRemoval of the solvent
출처 및 근거
- ORD 기록
- ord-994529cf00af43f8a4de1e002695a03b
- 출처 데이터셋
- uspto-grants-2003_08
- 특허 번호
- US06603008B1
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