Lithium Hydroxide → 4-(2-Methoxypropan-2-yl)benzoic acid

HRID 395732

반응식

HRID 395732 반응식
[CH3:1][O:2][C:3]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][CH:7]=1)([CH3:5])[CH3:4].[OH-].[Li+]>O1CCCC1.CO.C(OCC)C>[CH3:1][O:2][C:3]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1)([CH3:5])[CH3:4]

참가 물질

6

반응물 2

HCID 3939Lithium HydroxideHCID 181744854-(1-Methoxy-1-methyl-ethyl)-benzoic acid methyl ester

생성물 1

HCID 181744324-(2-Methoxypropan-2-yl)benzoic acid수율 84%

시약·촉매·용매 3

HCID 887Methanol용매HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of methyl 4-(1-methoxy-1-methylethyl)benzoate (120 mg, 0.57 mmol) in tetrahydrofuran (6 mL) and methanol (2 mL) was added 1 M aqueous lithium hydroxide (2 mL). After stirring for 2 h, the reaction mixture was diluted with diethyl ether and washed with 1 N hydrochloric acid (4 mL) and water (4 mL). The organic layer was dried (magnesium sulfate), filtered, and concentrated in vacuo to give 93 mg (84%) of the title compound.

후처리

  1. washwashed with 1 N hydrochloric acid (4 mL) and water (4 mL)
  2. dry with materialThe organic layer was dried (magnesium sulfate)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-67c9174a20dd4b938a98bd584a0d709b
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06605626B2

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