Stannous chloride dihydrate → HCID 178441966, 화합물

HRID 396132노트

반응식

HRID 396132 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[C:9](=O)[CH2:10][CH:11]([CH3:13])[CH3:12].[N:15]([O-])=O.[Na+].O.O.[Sn](Cl)Cl>O.Cl>[OH:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[NH:1][N:15]=[C:9]2[CH2:10][CH:11]([CH3:13])[CH3:12]

참가 물질

6

반응물 3

HCID 61436Stannous chloride dihydrateHCID 230030541-(2-Amino-5-hydroxyphenyl)-3-methyl-1-butanoneHCID 23668193Sodium Nitrite

생성물 1

HCID 178441966HCID 178441966, 화합물수율 41.1%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매2회HCID 962Water용매

실험 절차

In an analogous manner to the procedure of Example XIV, 783 mg (4.05 mmol) of 1-(2-amino-5-hydroxyphenyl)-3-methyl-1-butanone in 30 ml of half-conc. hydrochloric acid are reacted with 294 mg (4.25 mmol) of sodium nitrite in 15 ml of water and 914 mg (4.05 mmol) of tin(II) chloride dihydrate in 15 ml of conc. hydrochloric acid to give 317 mg (41%) of 5-hydroxy-3-isobutyl-1H-indazole.

출처 및 근거

ORD 기록
ord-ac4c4b51e7d34aea93cc5e2f5f6ecc78
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608049B2

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