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Diisopropylethylamine → 1,1-Dimethylethyl 2-{[6-(2,4-dichlorophenyl)-5-nitropyrazin-2-yl]amino}ethylcarbamate

HRID 396166
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HRID 396166 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:10]([N+:16]([O-:18])=[O:17])=[N:11][CH:12]=[C:13](Br)[N:14]=1.[C:19]([NH:26][CH2:27][CH2:28][NH2:29])([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20].CCN(C(C)C)C(C)C>CN(C=O)C.C(OCC)(=O)C.O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([NH:29][CH2:28][CH2:27][NH:26][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH:12]=[N:11][C:10]=1[N+:16]([O-:18])=[O:17]
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참가 물질

7

반응물 3

HCID 81531DiisopropylethylamineHCID 187201N-BOC-ethylenediamineHCID 223185103-(2,4-Dichlorophenyl)-5-bromo-2-nitropyrazine

생성물 1

HCID 120860201,1-Dimethylethyl 2-{[6-(2,4-dichlorophenyl)-5-nitropyrazin-2-yl]amino}ethylcarbamate

시약·촉매·용매 3

HCID 962Water용매
HCID 6228
Dimethylformamide
용매
HCID 8857Ethyl Acetate용매

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온도
80 °C

실험 절차

To a solution of 3-(2,4-dichlorophenyl)-5-bromo-2-nitropyrazine (1.4 g, 4.0 mmol) in DMF (10 ml) were added Boc-ethylenediamine (960 mg, 6.0 mmol) and DIPEA (1.5 ml). The solution was stirred overnight at 80° C. The solution was cooled to room temperature, taken in ethyl acetate and water. The layers were separated and the organic layer was washed with water and brine, dried, concentrated and purified to afford the title product.

후처리

  1. temperatureThe solution was cooled to room temperature
  2. customThe layers were separated
  3. washthe organic layer was washed with water and brine
  4. customdried
  5. concentrationconcentrated
  6. custompurified

출처 및 근거

ORD 기록
ord-b61889c5d39c48bdb21ed41d49f74ecf
출처 데이터셋
uspto-grants-2003_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06608063B2

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