Sodium borohydride → 1-Benzyl-3,5-dimethyl-3-ethyl-4-hydroxypiperidine

HRID 396336노트

반응식

HRID 396336 반응식
[BH4-].[Na+].[CH2:3]([N:10]1[CH2:15][CH:14]([CH3:16])[C:13](=[O:17])[C:12]([CH3:20])([CH2:18][CH3:19])[CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO>[CH2:3]([N:10]1[CH2:15][CH:14]([CH3:16])[CH:13]([OH:17])[C:12]([CH3:20])([CH2:18][CH3:19])[CH2:11]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 222788971-Benzyl-3,5-dimethyl-3-ethyl-4-piperidone

생성물 1

HCID 230036911-Benzyl-3,5-dimethyl-3-ethyl-4-hydroxypiperidine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium borohydride (0.8 g, 21.0 mmole) was added to the stirred solution of 1-benzyl-3,5-dimethyl-3-ethylpiperidin-4-one (3.0 g, 12.25 mmole) in methanol (10 ml) at 0-5° C. over a period of 5 min, and stirring was continued for 1 hr at ambient temperature. The reaction mixture was concentrated to dryness, triturated with water (20 ml) and extracted with ethyl acetate. The ethyl acetate extract was dried (Na2SO4) and concentrated to dryness to furnish 1-benzyl-3,5-dimethyl-3-ethyl-4-hydroxypiperidine as oil. Yield 2.9 g (96%), C16H25NO, m/z 248 (M+l).

후처리

  1. concentrationThe reaction mixture was concentrated to dryness
  2. customtriturated with water (20 ml)
  3. extractionextracted with ethyl acetate
  4. extractionThe ethyl acetate extract
  5. dry with materialwas dried (Na2SO4)
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-ac55d4964267439ca917bce9b4151072
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608078B2

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