methyl[5-chloro-2-(4-ethyl-3-fluoropyridine-2-carbonyl)-1H-indol-3-yl]acetate → [5-Chloro-2-(4-ethyl-3-fluoropyridine-2-carbonyl)-1H-indol-3-yl]acetic Acid

HRID 396495노트

반응식

HRID 396495 반응식
C[O:2][C:3](=[O:26])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([Cl:14])[CH:12]=2)[NH:7][C:6]=1[C:15]([C:17]1[C:22]([F:23])=[C:21]([CH2:24][CH3:25])[CH:20]=[CH:19][N:18]=1)=[O:16]>C(O)(=O)C.Cl>[Cl:14][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:15]([C:17]1[C:22]([F:23])=[C:21]([CH2:24][CH3:25])[CH:20]=[CH:19][N:18]=1)=[O:16])=[C:5]2[CH2:4][C:3]([OH:26])=[O:2]

참가 물질

4

반응물 1

HCID 23003366methyl[5-chloro-2-(4-ethyl-3-fluoropyridine-2-carbonyl)-1H-indol-3-yl]acetate

생성물 1

HCID 18542322[5-Chloro-2-(4-ethyl-3-fluoropyridine-2-carbonyl)-1H-indol-3-yl]acetic Acid수율 93%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 313Hydrochloric Acid용매

실험 절차

A stirred solution of methyl[5-chloro-2-(4-ethyl-3-fluoropyridine-2-carbonyl)-1H-indol-3-yl]acetate (Example 111, 391.2 mg, 1.044 mmol) in acetic acid (12 ml) and 2N aqueous HCl (4 ml) was heated at reflux temperature for 24 h. After cooling to room temperature, the resulting mixture was concentrated. The residue was diluted in THF (100 ml), dried (MgSO4) and concentrated. The crude product was purified by recrystallization to afford 349.2 mg (93%) of the title compound.

후처리

  1. temperatureat reflux temperature for 24 h
  2. concentrationthe resulting mixture was concentrated
  3. additionThe residue was diluted in THF (100 ml)
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated
  6. customThe crude product was purified by recrystallization

출처 및 근거

ORD 기록
ord-489dbe877c0d4f6698843ec78e7566a7
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608070B1

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