Sulfuric Acid → Phenol, 3-bromo-, 1-acetate

HRID 396789노트

반응식

HRID 396789 반응식
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.S(=O)(=O)(O)O.C([O-])(O)=O.[Na+].[C:19](OC(=O)C)(=[O:21])[CH3:20]>O>[C:19]([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)(=[O:21])[CH3:20]

참가 물질

6

반응물 4

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 115633-BromophenolHCID 516892Sodium Bicarbonate

생성물 1

HCID 141946Phenol, 3-bromo-, 1-acetate수율 99%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred solution of 3-bromophenol (25 g, 145 mmol) in acetic anhydride (14 ml) was added a few drop of sulfuric acid, and the mixture was stirred for 2 hours. The mixture was poured into a solution of NaHCO3 (1.3 g, 15.5 mmol) in water (160 ml). The whole was extracted with diethylether. The organic layer was washed with saturated NaHCO3 aqueous solution, brine, dried over MgSO4, and concentrated in vacuo. The residue was used for next reaction without purification. (31 g, 99% yield).

후처리

  1. extractionThe whole was extracted with diethylether
  2. washThe organic layer was washed with saturated NaHCO3 aqueous solution, brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo
  5. customThe residue was used for next reaction without purification

출처 및 근거

ORD 기록
ord-d03daa0cdf5640529f69289a7f618800
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608095B2

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