Diethylethanolamine → (2S)-2-[isobutyl(p-tolylsulfonyl)amino]-6-[[2-(3-quinolylamino)acetyl]amino]hexanoic acid

HRID 396920

반응식

HRID 396920 반응식
[CH2:1]([N:5]([S:19]([C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=1)(=[O:21])=[O:20])[C@H:6]([C:16]([OH:18])=[O:17])[CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:15])[CH2:13]I)[CH:2]([CH3:4])[CH3:3].CCN(CCO)CC.[NH2:37][C:38]1[CH:39]=[N:40][C:41]2[C:46]([CH:47]=1)=[CH:45][CH:44]=[CH:43][CH:42]=2>>[CH3:28][C:25]1[CH:26]=[CH:27][C:22]([S:19]([N:5]([C@H:6]([C:16]([OH:18])=[O:17])[CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([CH2:13][NH:37][C:38]2[CH:39]=[N:40][C:41]3[C:46](=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH:47]=2)=[O:15])[CH2:1][CH:2]([CH3:4])[CH3:3])(=[O:21])=[O:20])=[CH:23][CH:24]=1

참가 물질

4

반응물 3

HCID 7497DiethylethanolamineHCID 113753-AminoquinolineHCID 86589941Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-Nepsilon-iodoacetyl-L-lysine

생성물 1

HCID 508635(2S)-2-[isobutyl(p-tolylsulfonyl)amino]-6-[[2-(3-quinolylamino)acetyl]amino]hexanoic acid

실험 절차

The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-Nε-iodoacetyl-L-lysine (200 mg, 0.38 mmol, example 105, step B) by following the indications of general procedure H using DEEA (0.19 mL, 1.09 mmol) and 3-aminoquinoline (260 mg, 1.80 mmol). The crude material was purified by preparative HPLC. The product was isolated as a solid (24 mg, 12% yield).

후처리

  1. customThe crude material was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-07c27e65f06a4608a1a4de6bc4334e25
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608100B1

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