Hexane → 1-(4-Bromophenyl)-6-methoxy-3,4-dihydroisoquinoline hydrochloride

HRID 397052노트

반응식

HRID 397052 반응식
[Br:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:22].CCCCCC>C(Cl)(Cl)Cl>[ClH:22].[Br:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=3)[CH2:10][CH2:9][N:8]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 8058HexaneHCID 24819Phosphorus pentachlorideHCID 110241034-bromo-N-[2-(3-methoxyphenyl)ethyl]benzamide

생성물 1

HCID 181724611-(4-Bromophenyl)-6-methoxy-3,4-dihydroisoquinoline hydrochloride수율 69%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of 4-bromo-N-[2-(3-methoxyphenyl)ethyl]benzamide (5.00 g, 15.0 mmol) in CHCl3 (30 ml) was added phosphorous pentachloride (5.30 g, 25.0 mmol) and the mixture stirred for 18 hr at rt under N2. Hexane was added to the mixture and the liquid was then decanted off. EtOH (15 ml) was added to the residue and the mixture was triturated with diethyl ether to give 3.65 g (69% yield) of off-white solid.

후처리

  1. customthe liquid was then decanted off
  2. additionEtOH (15 ml) was added to the residue
  3. customthe mixture was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-1ac3f707267e41fa8e00cbe33e0b9d5b
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608203B2

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