Sodium Acetate → HCID 18172391, 화합물

HRID 397088

반응식

HRID 397088 반응식
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]3[C:24]4[C:19](=[CH:20][C:21]([OH:25])=[CH:22][CH:23]=4)[CH2:18][CH2:17][NH:16]3)=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:26]1([C:31]2[CH:38]=[CH:37][C:34]([CH:35]=O)=[CH:33][CH:32]=2)[CH:30]=[CH:29][N:28]=[CH:27]1.CC([O-])=O.[Na+].C([BH3-])#N.[Na+]>CO>[N:26]1([C:31]2[CH:38]=[CH:37][C:34]([CH2:35][N:16]3[CH2:17][CH2:18][C:19]4[C:24](=[CH:23][CH:22]=[C:21]([OH:25])[CH:20]=4)[CH:15]3[C:12]3[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH2:6][N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)=[CH:10][CH:11]=3)=[CH:33][CH:32]=2)[CH:30]=[CH:29][N:28]=[CH:27]1

참가 물질

6

반응물 4

HCID 517045Sodium AcetateHCID 7365304-(1H-imidazol-1-yl)benzaldehydeHCID 5003444Sodium cyanoborohydrideHCID 181724491-[4-(2-Pyrrolidin-1-yl-ethoxy)phenyl]-1,2,3,4-tetrahydroisoquinolin-6-ol

생성물 1

HCID 18172391HCID 18172391, 화합물수율 112.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-1,2,3,4-tetrahydroisoquinolin-6-ol (0.023 g, 0.067 mmol), 4-imidazol-1-yl-benzaldehyde (0.011 g, 0.063 mmol), NaOAc (0.011 g, 0.14 mmol), and sodium cyanoborohydride (0.004 g, 0.063 mmol) in MeOH (2.0 ml) was stirred at rt for 18 hr. The reaction mixture was evaporated in vacuo to a yellow residue that was dissolved in EtOAc (5 ml) and washed first with sat. NaHCO3 solution (5 ml) and then with H2O (5 ml). The organic solution was dried over MgSO4 and evaporated to give 0.035 g of yellow residue. Purification by preparative TLC, eluting with EtOAc:MeOH (7:3), gave 0.007 g (23% yield) of white solid.

후처리

  1. customThe reaction mixture was evaporated in vacuo to a yellow residue that
  2. dissolutionwas dissolved in EtOAc (5 ml)
  3. washwashed first with sat. NaHCO3 solution (5 ml)
  4. dry with materialThe organic solution was dried over MgSO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-ca3227ff177140879ce3c5041d487307
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608203B2

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