Methyl phenylacetate → Benzeneacetic acid, alpha-bromo-, methyl ester

HRID 3973

반응식

HRID 3973 반응식
[Br:1]N1C(=O)CCC1=O.[C:9]1([CH2:15][C:16]([O:18][CH3:19])=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:1][CH:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:16]([O:18][CH3:19])=[O:17]

참가 물질

5

반응물 2

HCID 7559Methyl phenylacetateHCID 67184N-bromobutanimide

생성물 1

HCID 137806Benzeneacetic acid, alpha-bromo-, methyl ester수율 93.1%

시약·촉매·용매 2

HCID 7187Benzoyl Peroxide촉매HCID 5943Carbon Tetrachloride용매

반응 조건

온도
0 °C

실험 절차

In this example, a mixture containing 5.93 g of N-bromosuccinimide, 5.0 g of methyl phenylacetate; and a catalytic amount (about 0.1 g) of benzoyl peroxide in 50 ml of carbon tetrachloride was warmed to reflux and then refluxed for about 12 hours. The mixture was then cooled to about 0° C. and filtered. The filtrate was concentrated by evaporation under vacuum affording 7.1 g of the title compound as an oil.

후처리

  1. temperatureto reflux
  2. temperaturerefluxed for about 12 hours
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated by evaporation under vacuum

출처 및 근거

ORD 기록
ord-5dcd18cf32f744b38e1a3a9e2e554156
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723031

연결된 노트

불러오는 중…