Methyl phenylacetate → Benzeneacetic acid, alpha-bromo-, methyl ester
반응식
[Br:1]N1C(=O)CCC1=O.[C:9]1([CH2:15][C:16]([O:18][CH3:19])=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:1][CH:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:16]([O:18][CH3:19])=[O:17]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
In this example, a mixture containing 5.93 g of N-bromosuccinimide, 5.0 g of methyl phenylacetate; and a catalytic amount (about 0.1 g) of benzoyl peroxide in 50 ml of carbon tetrachloride was warmed to reflux and then refluxed for about 12 hours. The mixture was then cooled to about 0° C. and filtered. The filtrate was concentrated by evaporation under vacuum affording 7.1 g of the title compound as an oil.
후처리
- temperatureto reflux
- temperaturerefluxed for about 12 hours
- filtrationfiltered
- concentrationThe filtrate was concentrated by evaporation under vacuum
출처 및 근거
- ORD 기록
- ord-5dcd18cf32f744b38e1a3a9e2e554156
- 출처 데이터셋
- uspto-grants-1988_02
- 특허 번호
- US04723031
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