N-Iodosuccinimide → 6-cyclopropoxy-8-iodo-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene

HRID 397320노트

반응식

HRID 397320 반응식
[I:1]N1C(=O)CCC1=O.[CH:9]1([O:12][C:13]2[CH:21]=[CH:20][C:19]3[N:18]4[CH2:22][CH2:23][CH2:24][C:17]4=[CH:16][C:15]=3[CH:14]=2)[CH2:11][CH2:10]1>C(#N)C>[CH:9]1([O:12][C:13]2[CH:21]=[CH:20][C:19]3[N:18]4[CH2:22][CH2:23][CH2:24][C:17]4=[C:16]([I:1])[C:15]=3[CH:14]=2)[CH2:11][CH2:10]1

참가 물질

4

반응물 2

HCID 120273N-IodosuccinimideHCID 230001076-Cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene

생성물 1

HCID 230001116-cyclopropoxy-8-iodo-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene수율 72.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

18.5 g N-iodosuccinimide at 0° C. was added to a solution of 17.55 g 6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene in acetonitrile and the mixture was stirred at this temperature for 15 min. The solid was collected by filtration, washed with cold acetonitrile and dried to constant weight to yield 20.1 g 6-cyclopropoxy-8-iodo-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene as beige crystals melting at 104-105° C.

후처리

  1. filtrationThe solid was collected by filtration
  2. washwashed with cold acetonitrile
  3. customdried to constant weight

출처 및 근거

ORD 기록
ord-0c9f49d70225419a963bb6fba251828d
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610685B2

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