Hydrochloric Acid → (S)-2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethylamine hydrochloride

HRID 397322노트

반응식

HRID 397322 반응식
C(OC(=O)[NH:7][C@@H:8]([CH3:26])[CH2:9][C:10]1[C:18]2[CH:17]=[C:16]([O:19][CH:20]3[CH2:22][CH2:21]3)[CH:15]=[CH:14][C:13]=2[N:12]2[CH2:23][CH2:24][CH2:25][C:11]=12)(C)(C)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[CH:20]1([O:19][C:16]2[CH:15]=[CH:14][C:13]3[N:12]4[CH2:23][CH2:24][CH2:25][C:11]4=[C:10]([CH2:9][C@@H:8]([NH2:7])[CH3:26])[C:18]=3[CH:17]=2)[CH2:21][CH2:22]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 69363623(S)-[2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

생성물 1

HCID 21355889(S)-2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethylamine hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

A solution of 11.81 g (S)-[2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester in 120 mL of a 2.26 M solution of hydrochloric acid in ethyl acetate was stirred at room temperature for 2 h. The resulting suspension was diluted with 120 mL ethyl acetate and the product collected by filtration, washed with ethyl acetate and dried to constant weight under high vacuum to yield 8.65 g (S)-2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethylamine hydrochloride as white crystals melting at 214-217° C.

후처리

  1. filtrationthe product collected by filtration
  2. washwashed with ethyl acetate
  3. customdried to constant weight under high vacuum

출처 및 근거

ORD 기록
ord-cae8b87ba305480e97f6a9ed922b281e
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610685B2

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