8-Methylquinoline → Quinoline, 8-methyl-, 1-oxide

HRID 39733

반응식

HRID 39733 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.ClC1C=CC=C(C(OO)=[O:20])C=1.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N+:10]([O-:20])=[CH:9][CH:8]=[CH:7]2

참가 물질

5

반응물 3

HCID 119108-MethylquinolineHCID 70297m-Chloroperbenzoic acid2회HCID 516892Sodium Bicarbonate

생성물 1

HCID 12488418Quinoline, 8-methyl-, 1-oxide

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To 40 mL of a chloroform solution containing 2.0 g of 8-methylquinoline, 3.6 g of m-chloroperbenzoic acid was added, and the mixture was stirred at room temperature overnight. Thereto was added 1.0 g of m-chloroperbenzoic acid, and the mixture was stirred at room temperature overnight. An aqueous saturated sodium hydrogen carbonate solution was added to the reaction mixture, the organic layer was separated, and the aqueous layer was extracted with chloroform. The organic layer and the extract were combined, the resultant solution was washed with an aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 2.2 g of a brown oily substance, 8-methylquinoline N-oxide.

후처리

  1. additionwas added
  2. stirringthe mixture was stirred at room temperature overnight
  3. customthe organic layer was separated
  4. extractionthe aqueous layer was extracted with chloroform
  5. washthe resultant solution was washed with an aqueous saturated sodium chloride solution
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-6ad15f2d3e544c06b2ee4d550dd2382c
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524738B2

연결된 노트

불러오는 중…