Water → Methyl 2-(methylamino)-2-phenylacetate

HRID 3974

반응식

HRID 3974 반응식
Br[CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[Cl-].[CH3:14][NH3+:15].C(=O)(O)[O-].[Na+].O>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)Cl>[CH3:14][NH:15][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4]

참가 물질

7

반응물 4

HCID 962WaterHCID 11637Methanamine, hydrochloride (1:1)HCID 137806Benzeneacetic acid, alpha-bromo-, methyl esterHCID 516892Sodium Bicarbonate

생성물 1

HCID 13852358Methyl 2-(methylamino)-2-phenylacetate수율 71.2%

시약·촉매·용매 2

HCID 66133Benzyl triethylammonium chloride촉매HCID 6344Dichloromethane용매

실험 절차

In this example a mixture containing 30.7 g of methyl bromo-phenylacetate, 36.2 g of methyl ammonium chloride (i.e. CH3NH3Cl); 3.0 g of benzyltriethylammonium chloride and 67.5 g of sodium bicarbonate in about 300 ml of methylene chloride (and about 25 ml of water) was warmed to refluxed and refluxed for about 18 hours. The mixture was then cooled and washed three times with water, dried over magnesium sulfate and concentrated by vacuum evaporation affording 17.1 g of the title compound as an oil.

후처리

  1. temperatureto refluxed
  2. temperaturerefluxed for about 18 hours
  3. temperatureThe mixture was then cooled
  4. washwashed three times with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated by vacuum evaporation

출처 및 근거

ORD 기록
ord-c156814239954cc794d18661347d1e7d
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723031

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