Water → Methyl 2-(methylamino)-2-phenylacetate
반응식
Br[CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[Cl-].[CH3:14][NH3+:15].C(=O)(O)[O-].[Na+].O>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)Cl>[CH3:14][NH:15][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4]참가 물질
7
실험 절차
In this example a mixture containing 30.7 g of methyl bromo-phenylacetate, 36.2 g of methyl ammonium chloride (i.e. CH3NH3Cl); 3.0 g of benzyltriethylammonium chloride and 67.5 g of sodium bicarbonate in about 300 ml of methylene chloride (and about 25 ml of water) was warmed to refluxed and refluxed for about 18 hours. The mixture was then cooled and washed three times with water, dried over magnesium sulfate and concentrated by vacuum evaporation affording 17.1 g of the title compound as an oil.
후처리
- temperatureto refluxed
- temperaturerefluxed for about 18 hours
- temperatureThe mixture was then cooled
- washwashed three times with water
- dry with materialdried over magnesium sulfate
- concentrationconcentrated by vacuum evaporation
출처 및 근거
- ORD 기록
- ord-c156814239954cc794d18661347d1e7d
- 출처 데이터셋
- uspto-grants-1988_02
- 특허 번호
- US04723031
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