Sodium Hydroxide → N-[6-[3-[4-(Diphenylmethoxy)piperidino]propylamino][1,2,4]triazolo[4,3-b]pyridazine-3-carbonyl]-2,2-dimethylglycine

HRID 397567노트

반응식

HRID 397567 반응식
C([O:3][C:4](=[O:44])[C:5]([CH3:43])([CH3:42])[NH:6][C:7]([C:9]1[N:13]2[N:14]=[C:15]([NH:18][CH2:19][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][CH:25]([O:28][CH:29]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)[C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH2:24][CH2:23]3)[CH:16]=[CH:17][C:12]2=[N:11][N:10]=1)=[O:8])C.[OH-].[Na+]>C(O)C>[C:36]1([CH:29]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[O:28][CH:25]2[CH2:24][CH2:23][N:22]([CH2:21][CH2:20][CH2:19][NH:18][C:15]3[CH:16]=[CH:17][C:12]4[N:13]([C:9]([C:7]([NH:6][C:5]([CH3:43])([CH3:42])[C:4]([OH:44])=[O:3])=[O:8])=[N:10][N:11]=4)[N:14]=3)[CH2:27][CH2:26]2)[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 23000293N-[6-[3-[4-(Diphenylmethoxy)piperidino]propylamino][1,2,4]triazolo[4,3-b]pyridazine-3-carbonyl]-2,2-dimethylglycine Ethyl Ester

생성물 1

HCID 23000286N-[6-[3-[4-(Diphenylmethoxy)piperidino]propylamino][1,2,4]triazolo[4,3-b]pyridazine-3-carbonyl]-2,2-dimethylglycine수율 77.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

830 mg of N-[6-[3-[4-(diphenylmethoxy)piperidino]propylamino][1,2,4]triazolo[4,3-b]pyridazine-3-carbonyl]-2,2-dimethylglycine ethyl ester was dissolved in 10 ml of ethanol; 3.2 ml of a 1 N aqueous solution of sodium hydroxide was added, followed by stirring at room temperature for 17 hours. After the ethanol was distilled off, 1 N hydrochloric acid was added to reach pH 4.5. The precipitated crystal was collected by filtration, washed with water and ethanol, and dried, to yield 610 mg of the title compound.

후처리

  1. distillationAfter the ethanol was distilled off
  2. addition1 N hydrochloric acid was added
  3. filtrationThe precipitated crystal was collected by filtration
  4. washwashed with water and ethanol
  5. customdried

출처 및 근거

ORD 기록
ord-6eea1875d9df4f698012ccfe21e70077
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610694B1

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