5-Chloronaproxen, (S)- → Naproxen

HRID 3976

반응식

HRID 3976 반응식
Cl[C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([C@H:14]([CH3:18])[C:15]([OH:17])=[O:16])=[CH:7]2>[OH-].[Na+].[Al].[Ni]>[CH3:13][O:12][C:11]1[CH:2]=[C:3]2[C:8](=[CH:9][CH:10]=1)[CH:7]=[C:6]([C@H:14]([CH3:18])[C:15]([OH:17])=[O:16])[CH:5]=[CH:4]2

참가 물질

4

반응물 1

HCID 130752095-Chloronaproxen, (S)-

생성물 1

HCID 156391Naproxen

시약·촉매·용매 2

HCID 6336846Nickel aluminide촉매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of 1 g of (S)-2-(5-chloro-6-methoxy-2-naphthyl)-propionic acid in 20 ml of 10% aqueous sodium hydroxide solution at 90° C. is treated with 3 g of a nickel-aluminum alloy in small portions. After stirring the mixture for two hours, it is filtered, diluted with excess dilute hydrochloric acid and extracted with methylene chloride. The organic phase is evaporated to dryness and the residue recrystallized from methylene chloride/hexane to yield (S)-2-(6-methoxy-2-naphthyl)propionic acid after recrystallization.

후처리

  1. filtrationit is filtered
  2. additiondiluted with excess dilute hydrochloric acid
  3. extractionextracted with methylene chloride
  4. customThe organic phase is evaporated to dryness
  5. customthe residue recrystallized from methylene chloride/hexane

출처 및 근거

ORD 기록
ord-0089af8057e946a18b16755f3f9439f0
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723033

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