N-bromobutanimide → HCID 15895947, 화합물
반응식
[F:1][C:2]1[C:11]2[O:10][CH2:9][CH:8]([C:12]#[N:13])[O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.C1C(=O)N([Br:21])C(=O)C1>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[F:1][C:2]1[C:11]2[O:10][CH2:9][C:8]([Br:21])([C:12]#[N:13])[O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 70 °C
실험 절차
A solution containing 6.44 g of the nitrile obtained in Stage 2 (36 mmol), 6.40 g of NBS (36 mmol, 1 eq.), and 100 mg of benzoyl peroxide in 200 ml of CCl4 is heated at 70° C. for 48 hours. The mixture is allowed to cool to room temperature. The reaction mixture is then filtered. The solid is washed with CCl4 and the mother liquors are evaporated to dryness. 9.3 g of an orange-yellow oil are isolated (quantitative yield).
후처리
- temperatureto cool to room temperature
- filtrationThe reaction mixture is then filtered
- washThe solid is washed with CCl4
- customthe mother liquors are evaporated to dryness
출처 및 근거
- ORD 기록
- ord-9a90c428121445fb8387f17aa25f2f9f
- 출처 데이터셋
- uspto-grants-2003_08
- 특허 번호
- US06610725B1
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