Acetic Acid → HCID 23445018, 화합물

HRID 397930

반응식

HRID 397930 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1)[NH2:5].[CH:13](OCC)(OCC)OCC.[N+:23]([CH2:26]C(OCC)=O)([O-])=O.[C:32]([OH:35])(=[O:34])[CH3:33]>[Fe]>[F:1][C:2]1[CH:3]=[C:4]([N:5]2[CH:13]=[C:33]([C:32]([OH:35])=[O:34])[N:23]=[CH:26]2)[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

참가 물질

6

반응물 4

HCID 176Acetic Acid2회HCID 31214Ethyl orthoformate2회HCID 69379Ethyl nitroacetateHCID 27359133-Amino-5-fluorobenzotrifluoride

생성물 1

HCID 23445018HCID 23445018, 화합물

시약·촉매·용매 1

HCID 23925Iron촉매

실험 절차

Following the general method described in example 234, 3-fluoro-5-trifluoromethylaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a white crystalline solid. Mp.>250° C. (H2O/dioxane), MS: m/e=273 (M−H−).

출처 및 근거

ORD 기록
ord-b147aa1cff6e43aeaab32b572cddd72d
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610723B2

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