Iodine chloride → 8Iodo-2,2,4,4-tetramethy-6-chromanoic Acid

HRID 398058노트

반응식

HRID 398058 반응식
[CH3:1][C:2]1([CH3:17])[CH2:11][C:10]([CH3:13])([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:14]([OH:16])=[O:15])[CH:8]=2)[O:3]1.[I:18]Cl.BrC1C=C(C(O)=O)C=C2C=1OC(C)(C)CC2(C)C>CC(O)=O>[I:18][C:5]1[CH:6]=[C:7]([C:14]([OH:16])=[O:15])[CH:8]=[C:9]2[C:4]=1[O:3][C:2]([CH3:17])([CH3:1])[CH2:11][C:10]2([CH3:12])[CH3:13]

참가 물질

5

반응물 3

HCID 24640Iodine chlorideHCID 157287092,2,4,4-Tetramethyl-3,4-dihydro-2H-1-benzopyran-6-carboxylic acidHCID 158405358-Bromo-2,2,4,4-tetramethyl-6-chromanoic acid2회

생성물 1

HCID 230017638Iodo-2,2,4,4-tetramethy-6-chromanoic Acid수율 106.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 2,2,4,4-tetramethyl-6-chromanoic acid (66 mg, 0.28 mmol) in 0.8 ml of AcOH was added ICl (0.07 ml, 1.4 mmol). The resulting colored solution was stirred at room temperature for overnight. Following the same procedure as for the synthesis of 8-bromo-2,2,4,4-tetramethyl-6-chromanoic acid (Compound P), the reaction gave the title compound (107 mg) as white solids.

출처 및 근거

ORD 기록
ord-4373544e45264bb59b9adcb73541a31d
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610744B2

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