Acetic Anhydride → HCID 23000218, 화합물

HRID 398339노트

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HRID 398339 반응식
[CH2:1]([NH:6][C:7]1[N:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH2:2][CH2:3][C:4]#[CH:5].[C:13](OC(=O)C)(=[O:15])[CH3:14]>S(=O)(=O)(O)O>[C:13]([N:6]([C:7]1[N:8]=[CH:9][CH:10]=[CH:11][N:12]=1)[CH2:1][CH2:2][CH2:3][C:4]#[CH:5])(=[O:15])[CH3:14]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 23000157HCID 23000157, 화합물

생성물 1

HCID 23000218HCID 23000218, 화합물

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

반응 조건

온도
90 °C

실험 절차

A mixture of 2-(pent-4-ynylamino)pyrimidine (4.25 g, 26.4 mmol) and concentrated sulfuric acid (5 drops) in acetic anhydride (100 mL) was heated to 90° C. for 16 h. The mixture was cooled and partitioned between water and methylene chloride. The organic layer was dried (Na2SO4), filtered through a pad of silica and evaporated in vacuo to give the title compound:

후처리

  1. temperatureThe mixture was cooled
  2. custompartitioned between water and methylene chloride
  3. dry with materialThe organic layer was dried (Na2SO4)
  4. filtrationfiltered through a pad of silica
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-e02d4bac52b5495cb5fce07d72447cfb
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610692B1

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