Dichloromethane → 1H-Indazole-5-carbonitrile

HRID 398355노트

반응식

HRID 398355 반응식
[C:1]([C:3]1[CH:4]=[CH:5][C:6](F)=[C:7]([CH:10]=1)[CH:8]=O)#[N:2].C(Cl)Cl.O.[NH2:16][NH2:17]>>[C:1]([C:3]1[CH:10]=[C:7]2[C:6](=[CH:5][CH:4]=1)[NH:17][N:16]=[CH:8]2)#[N:2]

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 24654Hydrazine hydrate (1:1)HCID 109097255-Cyano-2-fluorobenzaldehyde

생성물 1

HCID 111263841H-Indazole-5-carbonitrile

실험 절차

5-Cyano-2-fluorobenzaldehyde (512 mg, 3.43 mmol) was dissolved in hydrazine hydrate (25 mL) at room temperature and the solution left to stand overnight. To this reaction mixture was added methylene chloride (30 mL). The mixture was purified by filtration through a pad of silica eluting with methylene chloride, concentrated in vacuo to afford a white solid:

후처리

  1. waitthe solution left
  2. filtrationThe mixture was purified by filtration through a pad of silica eluting with methylene chloride
  3. concentrationconcentrated in vacuo
  4. customto afford a white solid

출처 및 근거

ORD 기록
ord-af8254012b4749e383f127b9a2eb1307
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610692B1

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