Chlorotrimethylsilane → 2-Methyl-N,N-bis(trimethylsilyl)pyrimidin-4-amine

HRID 398691

반응식

HRID 398691 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[N:3]=1.Cl[Si:10]([CH3:13])([CH3:12])[CH3:11]>C[Si](C)(C)N[Si](C)(C)C>[CH3:11][Si:10]([CH3:13])([CH3:12])[N:1]([C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[N:3]=1)[Si:10]([CH3:13])([CH3:12])[CH3:11]

참가 물질

4

반응물 2

HCID 6397ChlorotrimethylsilaneHCID 2957632-Methylpyrimidin-4-amine

생성물 1

HCID 223152262-Methyl-N,N-bis(trimethylsilyl)pyrimidin-4-amine수율 614.3%

시약·촉매·용매 1

HCID 13838Hexamethyldisilazane용매

실험 절차

A slurry of 4-amino-2-methylpyrimidine (2.04 g, 18.69 mmol) in 1,1,1,3,3,3-hexamethyldisilazane (40 mL) and chlorotrimethylsilane (0.36 mL, 2.8 mmol) was heated at 150° C. for 8 h. At this time, the reaction mixture was close to a homogeneous solution. The resulting slightly orange solution was then filtered to remove any remaining solids. The filtrate was concentrated in vacuo to afford 4-(1,1,1,3,3,3-hexamethyl-disilazan-2-yl)-2-methyl-pyrimidine as an off-white solid (2.18 g).

후처리

  1. customAt this time, the reaction mixture was close to a homogeneous solution
  2. filtrationThe resulting slightly orange solution was then filtered
  3. customto remove any remaining solids
  4. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-f296f1bbe65447f89db266ae0b3412b9
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610846B1

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