Hydrochloric Acid → Eniluracil
반응식
C[Si]([C:5]#[C:6][C:7]1[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=1)(C)C.C[O-].[Na+].Cl>CO>[C:6]([C:7]1[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=1)#[CH:5]참가 물질
5
실험 절차
A solution of 5-(trimethylsilylethynyl)uracil (5.3g, 24.4mmol) in 0.2M solution of sodium methoxide in methanol (400 mL) was stirred at room temperature for 3 hours and neutralized to pH 7 with dilute hydrochloric acid. The precipitated product was filtered, washed with methanol and dried to give a first crop of the title compound. The filtrates and washings were combined, evaporated to dryness and the residue crystallised from methanol to give the second crop of product. Combination of both crops and a further recrystallisation from ethanol gave a pure product.
후처리
- filtrationThe precipitated product was filtered
- washwashed with methanol
- customdried
출처 및 근거
- ORD 기록
- ord-b1410f3131864dfb83db1ced24ae258b
- 출처 데이터셋
- uspto-grants-1998_10
- 특허 번호
- US05817664
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