Hydrochloric Acid → Pyridine, 2,4,6-trichloro-

HRID 398843

반응식

HRID 398843 반응식
N[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([Cl:9])[CH:3]=1.[ClH:10].N([O-])=O.[Na+].[Cl-].[Na+]>O>[Cl:8][C:6]1[CH:7]=[C:2]([Cl:10])[CH:3]=[C:4]([Cl:9])[N:5]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 1376524-Amino-2,6-dichloropyridineHCID 23668193Sodium Nitrite

생성물 1

HCID 27665Pyridine, 2,4,6-trichloro-

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture composed of 4-amino-2,6-dichloropyridine (5.5 g), cuprous chloride (4.4 g) and concentrated hydrochloric acid (50 ml), sodium nitrite (3.5 g) was added little by little under cooling with ice and sodium chloride. After the resultant mixture was stirred for one hour at the same temperature and for one and a half hour at a room temperature, water was added, and the mixture was extracted with chloroform. After the obtained extract was dried over anhydrous sodium sulfate, solvent was distilled off under reduced pressure to give 2,4,6-trichloropyridine (5.5 g).

후처리

  1. additionwas added little by little
  2. extractionthe mixture was extracted with chloroform
  3. extractionAfter the obtained extract
  4. dry with materialwas dried over anhydrous sodium sulfate, solvent
  5. distillationwas distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-36498c3c3f1340bab99605c8382e4339
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05817669

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