Methyl iodide → HCID 18969744, 화합물
반응식
[CH3:1][N:2]([CH3:11])[C:3](=[O:10])[CH2:4][C:5]1[CH:9]=[CH:8][S:7][CH:6]=1.[Li+].[CH3:13]C([N-]C(C)C)C.CI>C1COCC1>[CH3:11][N:2]([CH3:1])[C:3](=[O:10])[CH:4]([C:5]1[CH:9]=[CH:8][S:7][CH:6]=1)[CH3:13]참가 물질
5
실험 절차
To a solution of acetamide from Step 1 (510 mg) in THF (15 mL) at -78° C. was added LDA (mono THF, 1.5M, cyclohexane, 250 μL) followed by MeI (700 μL) after 30 min. The mixture was warmed to r.t., quenched with a saturated NH4Cl sol. and then extracted with Et2O. The organic phase was washed with H2O, brine, dried (MgSO4) and the solvents evaporated. The residue was purified by flash chromatography (silica gel; hexane/EtOAc (60:40)) to afford the title compound as a oil.
후처리
- customquenched with a saturated NH4Cl sol.
- extractionextracted with Et2O
- washThe organic phase was washed with H2O, brine
- dry with materialdried (MgSO4)
- customthe solvents evaporated
- customThe residue was purified by flash chromatography (silica gel; hexane/EtOAc (60:40))
출처 및 근거
- ORD 기록
- ord-94db0e5ad56541c6b9bafec4d3fad021
- 출처 데이터셋
- uspto-grants-1998_10
- 특허 번호
- US05817700
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