Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(Chlorothio)formyl chloride → Ethyl 2-hydroxy-4-methyl-1,3-thiazole-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (Chlorothio)formyl chloride | HCID 75990 | — |
| 반응물 | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 2-hydroxy-4-methyl-1,3-thiazole-5-carboxylate | HCID 11074139 | 62.4% |
반응 단계
25 g of chlorocarbonylsulphenyl chloride was added dropwise to 25 g of ethyl 3-aminocrotonate in 300 ml of toluene while being cooled with ice. The solution was heat-refluxed for 2 hours, and then cooled. The crystals precipitated were collected through filtration, and then washed twice with toluene to obtain 22.3 g of 4-methyl-5-ethoxycarbonyl-2-thiazolone as purple crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05817829 |
| 출처 데이터셋 | uspto-grants-1998_10 |
| ORD ID | ord-6ed8cb3f17d5497897d310ce6f90b851 |
| 출처 메모 | uspto-grants-1998_10 |