Hydrochloric Acid → 3-(2-Hydroxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane

HRID 399248노트

반응식

HRID 399248 반응식
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH:10]3[C:18]4[C:13](=[CH:14][C:15]([O:19][CH2:20][CH2:21][CH3:22])=[CH:16][CH:17]=4)[CH2:12][CH2:11]3)=[CH:4][C:3]=2[O:2]1.Cl.[CH3:24][OH:25]>>[OH:25][C:24]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[CH:12]1[C:13]2[C:18](=[CH:17][CH:16]=[C:15]([O:19][CH2:20][CH2:21][CH3:22])[CH:14]=2)[CH:10]([C:5]2[CH:6]=[CH:7][C:8]3[O:9][CH2:1][O:2][C:3]=3[CH:4]=2)[CH2:11]1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 184276791-(3,4-Methylenedioxyphenyl)-5-(prop 1-yloxy)indane

생성물 1

HCID 217130923-(2-Hydroxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane수율 94%

실험 절차

To a solution of (1RS,3RS)-3-[(2-methoxymethoxy)-4-methoxyphenyl)]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane (0.075 g, 0.16 mmol) in methanol (5 ml) was added 4-5 drops of 6M-HCl and the mixture refluxed for 1.5 h under argon. The solvent was removed in vacuo and the product partitioned between EtOAc and water. The organic extract was washed with water then sat. aq. NaHCO3 solution and finally brine. After drying (MgSO4 anhydrous) filtration and evaporation gave the title compound (0.064 g, 94%).

후처리

  1. temperaturethe mixture refluxed for 1.5 h under argon
  2. customThe solvent was removed in vacuo
  3. customthe product partitioned between EtOAc and water
  4. extractionThe organic extract
  5. washwas washed with water
  6. customAfter drying
  7. filtration(MgSO4 anhydrous) filtration and evaporation

출처 및 근거

ORD 기록
ord-1dd95b180c9e444cbc2a75d197c5bc5b
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05817693

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