Benzenesulfonyl chloride → 2'-Chloro-4'-nitrobenzenesulfonanilide

HRID 399477

반응식

HRID 399477 반응식
[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:12]1([S:18](Cl)(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][S:18]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:20])=[O:19]

참가 물질

4

반응물 2

HCID 7369Benzenesulfonyl chlorideHCID 84922-Chloro-4-nitroaniline

생성물 1

HCID 2318362'-Chloro-4'-nitrobenzenesulfonanilide

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2-chloro-4-nitroaniline (4.33 g), benzenesulphonyl chloride (3.25 ml) and pyridine (2.5 ml) was stirred and heated to 100° C. for 18 hours. The mixture was cooled to ambient temperature and partitioned between methylene chloride and 2M aqueous hydrochloric acid. The organic phase was washed with water, dried and evaporated. The residue was recrystallised from ethyl acetate to give N-(2-chloro-4-nitrophenyl)benzenesulphonamide (6.07 g), m.p. 155°-157° C.

후처리

  1. temperatureThe mixture was cooled to ambient temperature
  2. custompartitioned between methylene chloride and 2M aqueous hydrochloric acid
  3. washThe organic phase was washed with water
  4. customdried
  5. customevaporated
  6. customThe residue was recrystallised from ethyl acetate

출처 및 근거

ORD 기록
ord-c466971758344711aafc5413143c01f3
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05821246

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