Hydrogen chloride-ethyl acetate → HCID 67537667, 화합물

HRID 39963노트

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HRID 39963 반응식
[C:1]1([C:7]#[C:8][CH2:9][N:10]([CH2:31][C:32]#[C:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([F:29])[CH:27]=4)[N:22]=[CH:21][C:20]3=[O:30])[CH2:13][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:40].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:40].[C:34]1([C:33]#[C:32][CH2:31][N:10]([CH2:9][C:8]#[C:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([F:29])[CH:27]=4)[N:22]=[CH:21][C:20]3=[O:30])[CH2:13][CH2:12]2)[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593983021-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one

생성물 1

HCID 67537667HCID 67537667, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To 5 mL of a chloroform solution containing 132 mg of 1-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one, 0.5 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 141 mg of 1-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one hydrochloride as a pale brown solid.

후처리

  1. additionwas added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

출처 및 근거

ORD 기록
ord-909734bbe43f478ebf7f2169d2ef9646
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524738B2

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