Methyl iodide → 3,8-Dimethoxy quinoline
반응식
[OH:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[O:12][CH3:13].[OH-].[K+].I[CH3:17]>C(O)C>[CH3:17][O:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[O:12][CH3:13]참가 물질
5
실험 절차
175 mg of 3-hydroxy-8-methoxy quinoline [compound (V)] prepared in example 6 and 66 mg of potassium hydroxide were added to 3 ml of ethanol, and the solution was agitated for 30 minutes. To the solution was added 284 mg of iodomethane, and the solution was agitated for 24 hours. The solvent was removed, and the solution was extracted with dichloromethane. The dichloromethane layer was washed with water and aqueous sodium hydroxide, and dried with anhydrous magnesium sulfate. The dichloromethane was removed by vacuum distillation to give 165 mg of 3,8-dimethoxy quinoline.
후처리
- stirringthe solution was agitated for 24 hours
- customThe solvent was removed
- extractionthe solution was extracted with dichloromethane
- washThe dichloromethane layer was washed with water and aqueous sodium hydroxide
- dry with materialdried with anhydrous magnesium sulfate
- customThe dichloromethane was removed by vacuum distillation
출처 및 근거
- ORD 기록
- ord-aaf958ebc6be4ebdac4f38df1b6371fc
- 출처 데이터셋
- uspto-grants-1998_10
- 특허 번호
- US05824689
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