7-fluoro-1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one → 7-fluoro-1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride

HRID 39996노트

반응식

HRID 39996 반응식
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:33])[N:9]2[CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][CH2:21][C:22]3[CH:23]=[CH:24][C:25]4[S:26][CH2:27][C:28](=[O:32])[NH:29][C:30]=4[N:31]=3)[CH2:16][CH2:15]2)=[CH:4][CH:3]=1.[ClH:34].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:34].[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:33])[N:9]2[CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][CH2:21][C:22]3[CH:23]=[CH:24][C:25]4[S:26][CH2:27][C:28](=[O:32])[NH:29][C:30]=4[N:31]=3)[CH2:18][CH2:19]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 159856347-fluoro-1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-oneHCID 21866389Hydrogen chloride-ethyl acetate

생성물 1

HCID 675384827-fluoro-1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To 5 mL of a chloroform solution containing 126 mg of 7-fluoro-1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one, 0.5 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 92 mg of 7-fluoro-1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a pale brown solid.

후처리

  1. additionwas added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

출처 및 근거

ORD 기록
ord-c3fa89b2d75448b79dac76c72aff4175
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524738B2

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