Diethyl Ether → N,N-Bis(2-chloroethyl)benzylamine hydrochloride

HRID 400044

반응식

HRID 400044 반응식
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][N:8]([CH2:16]CO)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(OCC)C.[CH:24]([Cl:27])(Cl)Cl>>[ClH:3].[Cl:3][CH2:6][CH2:7][N:8]([CH2:16][CH2:24][Cl:27])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

5

반응물 4

HCID 3283Diethyl EtherHCID 6212Chloroform2회HCID 75532,2'-((Phenylmethyl)imino)bisethanolHCID 24386Thionyl Chloride

생성물 1

HCID 2777881N,N-Bis(2-chloroethyl)benzylamine hydrochloride

실험 절차

Thionyl chloride (25.4 g, 130 mmol) and chloroform (20 mL) are combined. A solution of N,N-bis(2-hydroxyethyl)-N-benzylamine (25.4 g, 130 mmol) in chloroform (20 mL) is added dropwise over 1 hour. When the addition is complete the reaction mixture is refluxed for 1 hour. The reaction mixture is cooled to ambient temperature and diethyl ether was added to form a solid which is collected by filtration, rinsed with diethyl ether, and dried to give the title compound.

후처리

  1. additionWhen the addition
  2. temperatureis refluxed for 1 hour
  3. customto form a solid which
  4. filtrationis collected by filtration
  5. washrinsed with diethyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-6c1b6c1007e243888166c6e6c8155072
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05824690

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