4-Bromophenylhydrazine hydrochloride → 3-Phthalimido-6-bromo-1,2,3,4-tetrahydrocarbazole

HRID 400180노트

반응식

HRID 400180 반응식
Cl.[Br:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9]N)=[CH:5][CH:4]=1.[C:11]1(=[O:28])[N:15]([CH:16]2[CH2:21][CH2:20][C:19](=O)[CH2:18][CH2:17]2)[C:14](=[O:23])[C:13]2=[CH:24][CH:25]=[CH:26][CH:27]=[C:12]12>C(O)CCC>[C:14]1(=[O:23])[N:15]([CH:16]2[CH2:17][C:18]3[C:7]4[C:6](=[CH:5][CH:4]=[C:3]([Br:2])[CH:8]=4)[NH:9][C:19]=3[CH2:20][CH2:21]2)[C:11](=[O:28])[C:12]2=[CH:27][CH:26]=[CH:25][CH:24]=[C:13]12

참가 물질

4

반응물 2

HCID 121574-Bromophenylhydrazine hydrochlorideHCID 119983912-(4-oxocyclohexyl)-2,3-dihydro-1H-isoindole-1,3-dione

생성물 1

HCID 189442543-Phthalimido-6-bromo-1,2,3,4-tetrahydrocarbazole수율 104.1%

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

Reaction of 4-bromophenylhydrazine hydrochloride (4.0g, 18.1 mmol) with 4-phthalimido-cyclohexanone (4.39g, 18.1 mmol) in refluxing n-butanol for 20 min, followed by cooling, filtration, and evaporation of the filtrate to dryness yielded 3-phthalimido-6-bromo-1,2,3,4-tetrahydrocarbazole as an orange solid (7.45g).

후처리

  1. temperatureby cooling
  2. filtrationfiltration, and evaporation of the filtrate to dryness

출처 및 근거

ORD 기록
ord-135e4bdb59fb4f3288ec1037b339041b
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05827871

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