Benzyl Bromide → Benzenemethanamine, N-hexyl-

HRID 400203

반응식

HRID 400203 반응식
[CH2:1]([NH2:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH2:8](Br)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[CH2:8]([NH:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

3

반응물 2

HCID 7498Benzyl BromideHCID 8102Hexylamine

생성물 1

HCID 485395Benzenemethanamine, N-hexyl-수율 89%

실험 절차

A! 200 ml (1.49 moles) of hexylamine cooled to 5° C. were added with benzyl bromide (42.3 ml, 0.35 mole), and the resultant mixture was stirred for 1 hour at room temperature. The hexylamine in excess was then distilled off under vacuum, and the residue dissolved in 300 ml of ethyl ether and washed with 200 ml of 0.5N sodium hydroxide. The ether phase was anhydrified over sodium sulfate and evaporated to dryness thus yielding 75.5 g of a crude which, by distillation under vacuum, gave 59 g (yield: 89%) of N-benzyl-N-hexylamine (b.p.--90°-95° C./0.6 mmHg).

후처리

  1. distillationThe hexylamine in excess was then distilled off under vacuum
  2. dissolutionthe residue dissolved in 300 ml of ethyl ether
  3. washwashed with 200 ml of 0.5N sodium hydroxide
  4. customevaporated to dryness
  5. customthus yielding 75.5 g of a crude which
  6. distillationby distillation under vacuum

출처 및 근거

ORD 기록
ord-b52e3838c7d1473386d8e76d81f29a25
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05827881

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