Tert-Butylamine → N-(1,1-Dimethylethyl)benzenesulfonamide

HRID 400301노트

반응식

HRID 400301 반응식
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].[C:6]1([S:12](Cl)(=[O:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1COCC1>[C:1]([NH:5][S:12]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:14])=[O:13])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 6385Tert-ButylamineHCID 7369Benzenesulfonyl chloride

생성물 1

HCID 314059N-(1,1-Dimethylethyl)benzenesulfonamide수율 95.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a cooled (0° C.) solution of tert-butylamine (42.9 mL, 410.6 mmol) in THF (840 mL) was added dropwise benzenesulfonyl chloride (26.2 mL, 205 mmol) and the reaction mixture was stirred at room temperature under an argon atmosphere for 6 h. The mixture was then filtered and the collected solid washed with THF. The filtrate was concentrated, redissolved in CH2Cl2 and washed with 0.1N HCl and H2O. The organic solution was dried and concentrated to afford the desired product (41.8 g, 95%).

후처리

  1. filtrationThe mixture was then filtered
  2. washthe collected solid washed with THF
  3. concentrationThe filtrate was concentrated
  4. dissolutionredissolved in CH2Cl2
  5. washwashed with 0.1N HCl and H2O
  6. customThe organic solution was dried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1b6044d52b904ce0a18f29ce5dce3756
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05827863

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