Thiourea → 5,6,7,8-tetrahydro-4H-Thiazolo[4,5-d]azepin-2-amine hydrobromide

HRID 400419노트

반응식

HRID 400419 반응식
[NH2:1][C:2]([NH2:4])=[S:3].Br.[Br:6][CH:7]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]1=O>C(O)C>[BrH:6].[S:3]1[C:7]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]=2[N:1]=[C:2]1[NH2:4]

참가 물질

4

반응물 2

HCID 2723790ThioureaHCID 226207665-Bromoazepan-4-one hydrobromide

생성물 1

HCID 866860295,6,7,8-tetrahydro-4H-Thiazolo[4,5-d]azepin-2-amine hydrobromide수율 103.7%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

1.44 g thiourea was added to 4 g 5-bromo-azepan-4-one hydrobromide in 50 mL ethanol and stirred 3 h at 80° C. and over the weekend at RT. The precipitate was filtered and dried to yield 3.8 g of the product.

후처리

  1. filtrationThe precipitate was filtered
  2. customdried

출처 및 근거

ORD 기록
ord-334573c84eeb444ba653e6d83bd3c910
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741892B2

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