Methanol → Methyl 2-methylisonicotinate

HRID 400444

반응식

HRID 400444 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=[O:6].[CH3:11]O>Cl>[CH3:11][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][N:10]=[C:2]([CH3:1])[CH:3]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 27628212-Methylpyridine-4-carboxylic acid

생성물 1

HCID 11542811Methyl 2-methylisonicotinate

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

5 g 2-methyl-isonicotinic acid was stirred 24 h at 50° C. in 150 mL 1.3 mol/L HCl in methanol. The solvent was removed and water was added to the residue. The mixture was basified with saturated sodiumhydrogencarbonate solution and extracted with ethylacetate. The organic layer was dried with magnesiumsulfate and evaporated to give 4.5 g of the desired product.

후처리

  1. customThe solvent was removed
  2. additionwater was added to the residue
  3. extractionextracted with ethylacetate
  4. dry with materialThe organic layer was dried with magnesiumsulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-2e0df64ed7db4a9abe1c7b7222727b7c
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741892B2

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