Hydrochloric Acid → 1-(5-Methyl-1,2,4-oxadiazol-3-yl)piperazine hydrochloride

HRID 400447노트

반응식

HRID 400447 반응식
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[N:19]=[C:18]([CH3:20])[O:17][N:16]=2)[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1.C(OCC)C>[ClH:1].[CH3:20][C:18]1[O:17][N:16]=[C:15]([N:12]2[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]2)[N:19]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 86686046tert-Butyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate

생성물 1

HCID 866860471-(5-Methyl-1,2,4-oxadiazol-3-yl)piperazine hydrochloride

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 312751,4-Dioxane용매2회

실험 절차

20 mL 4 mol/L HCl solution in dioxane was added to 3.35 g 4-(5-methyl-(1,2,4) oxadiazol-3-yl)-piperazine-1-carboxylic acid tert-butyl ester dissolved in 20 mL dioxane was stirred over night. The mixture was diluted with diethylether and the precipitate was filtered and washed with diethylether to give 2.5 g of the desired product.

후처리

  1. filtrationthe precipitate was filtered
  2. washwashed with diethylether

출처 및 근거

ORD 기록
ord-83cf5ceb544e4390b9c9ecf4e2f1b8c8
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741892B2

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