Water → 4-(4-Methyl-oxazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 400448노트

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HRID 400448 반응식
[OH-].[Na+].[C:3]([O:7][C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]#[N:17])[CH2:12][CH2:11]1)=[O:9])([CH3:6])([CH3:5])[CH3:4].[OH:18][CH2:19][C:20](=O)[CH3:21].O>C1COCC1.C(OCC)C>[C:3]([O:7][C:8]([N:10]1[CH2:11][CH2:12][N:13]([C:16]2[O:18][CH:19]=[C:20]([CH3:21])[N:17]=2)[CH2:14][CH2:15]1)=[O:9])([CH3:6])([CH3:4])[CH3:5]

참가 물질

7

반응물 4

HCID 962WaterHCID 8299HydroxyacetoneHCID 14798Sodium HydroxideHCID 14068968tert-Butyl 4-cyanopiperazine-1-carboxylate

생성물 1

HCID 866860484-(4-Methyl-oxazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
75 °C

실험 절차

17 mL 2 mol/L aqueous sodium hydroxide solution was dropped to 6.7 g 4-cyano-piperazine-1-carboxylic acid tert-butyl ester and 2.5 mL 1-hydroxy-propan-2-one in 10 mL THF. The reaction was stirred 12 h at RT and over night at 75° C. The reaction was cooled, water was added and the mixture was diluted with diethylether. The precipitate was filtered to give 1.32 g of the desired product.

후처리

  1. temperatureThe reaction was cooled
  2. filtrationThe precipitate was filtered

출처 및 근거

ORD 기록
ord-e3c0547f944e48b6a9cc2ca949ed6265
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741892B2

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