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2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → 2-Methyl-3-oxo-2,3,5,6,8,9-hexahydro-1,2,7-triaza-benzocycloheptene-7-carboxylic acid tert-butyl ester

HRID 400460
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인쇄 미리보기

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HRID 400460 반응식
C(C1C(=O)C(Cl)=C(Cl)C(=O)C=1C#N)#N.[C:15]([O:19][C:20]([N:22]1[CH2:28][CH2:27][C:26]2=[N:29][N:30]([CH3:34])[C:31](=[O:33])[CH2:32][CH:25]2[CH2:24][CH2:23]1)=[O:21])([CH3:18])([CH3:17])[CH3:16].C(=O)([O-])[O-].[K+].[K+]>O1CCOCC1>[C:15]([O:19][C:20]([N:22]1[CH2:28][CH2:27][C:26]2=[N:29][N:30]([CH3:34])[C:31](=[O:33])[CH:32]=[C:25]2[CH2:24][CH2:23]1)=[O:21])([CH3:18])([CH3:17])[CH3:16]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 11430Potassium CarbonateHCID 866860582-Methyl-3-oxo-2,3,4,4a,5,6,8,9-octahydro-1,2,7-triaza-benzocycloheptene-7-carboxylic acid tert-butyl ester

생성물 1

HCID 866860592-Methyl-3-oxo-2,3,5,6,8,9-hexahydro-1,2,7-triaza-benzocycloheptene-7-carboxylic acid tert-butyl ester수율 52.4%

시약·촉매·용매 1

HCID 31275
1,4-Dioxane
용매

실험 절차

3 g DDQ was added to 2.5 g 2-methyl-3-oxo-2,3,4,4a,5,6,8,9-octahydro-1,2,7-triaza-benzocycloheptene-7-carboxylic acid tert-butyl ester in 25 mL dioxane. The reaction was refluxed for 12 h. Then aqueous potassium carbonate solution was added and the mixture was extracted with chloroform. The organic layer was washed with brine. The crude product was purified by column chromatography on silica gel to yield 1.3 g of the desired product.

후처리

  1. temperatureThe reaction was refluxed for 12 h
  2. extractionthe mixture was extracted with chloroform
  3. washThe organic layer was washed with brine
  4. customThe crude product was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-3d7c3baae2f74170bb803737c9f5c040
출처 데이터셋
uspto-grants-2014_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08741892B2

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