Water → HCID 178497263, 화합물

HRID 400485

반응식

HRID 400485 반응식
C(O)(=O)C.[NH2:5][NH2:6].[CH3:7][O:8][C:9](=[O:21])[C:10](=O)[CH2:11][C:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.O>C(O)(=O)C>[CH3:7][O:8][C:9]([C:10]1[CH:11]=[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:6][N:5]=1)=[O:21]

참가 물질

5

반응물 3

HCID 962WaterHCID 165591Hydrazine, acetate (1:1)HCID 308117Methyl 2,4-dioxo-4-phenylbutanoate

생성물 1

HCID 178497263HCID 178497263, 화합물수율 66.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

983 mg hydrazine acetate was added to 2 g 2,4-Dioxo-4-phenyl-butyric acid methyl ester in 10 mL concentrated acetic acid. The mixture was stirred over night at RT. Then water was added. The precipitate was filtered, stirred with diisopropylether and again filtered to give 1.3 g desired product. Rt: 1.39 min (method O), (M+H)+: 203

후처리

  1. filtrationThe precipitate was filtered
  2. stirringstirred with diisopropylether
  3. filtrationagain filtered

출처 및 근거

ORD 기록
ord-8ffbecc03032464c90cc429146c8e351
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741892B2

연결된 노트

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