Potassium Carbonate → 3-(4-Fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl-acetic acid methyl ester

HRID 400486노트

반응식

HRID 400486 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.[C:20]([O-])([O-])=O.[K+].[K+].[CH3:26][O:27][C:28](=[O:31])[CH2:29]Br>CC(C)=O>[CH3:26][O:27][C:28](=[O:31])[CH2:29][N:9]1[C:8]([C:5]2[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=2)=[CH:12][C:11]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[C:15]([CH3:20])[CH:14]=2)=[N:10]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 161054793,5-bis(4-fluorophenyl)-1H-pyrazole

생성물 1

HCID 866860843-(4-Fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl-acetic acid methyl ester

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

3.6 g 3,5-Bis-(4-fluoro-phenyl)-1H-pyrazole, 8.8 g K2CO3 and 1.34 mL 2-bromoacetic acid methyl ester were dissolved in 100 mL acetone and stirred over night under reflux. K2CO3 was filtered and the solvent was removed. The residue was purified by HPLC (method 1) to yield 2.6 g of the desired product.

후처리

  1. temperatureunder reflux
  2. filtrationK2CO3 was filtered
  3. customthe solvent was removed
  4. customThe residue was purified by HPLC (method 1)

출처 및 근거

ORD 기록
ord-1ee8bcbcedf74419965b116b64dfc881
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741892B2

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